E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.

@article{Redmer2011EcadherinIC,
  title={E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.},
  author={Torben Redmer and Sebastian Diecke and Tamara Grigoryan and Angel Quiroga-Negreira and Walter Birchmeier and Daniel Besser},
  journal={EMBO reports},
  year={2011},
  volume={12 7},
  pages={720-6}
}
We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherin-positive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by… CONTINUE READING
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