E-cadherin is an additional immunological target for pemphigus autoantibodies.

@article{Evangelista2008EcadherinIA,
  title={E-cadherin is an additional immunological target for pemphigus autoantibodies.},
  author={Flor Tantalean Evangelista and David A. Dasher and Luis A Diaz and Phillip S Prisayanh and Ning Li},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 7},
  pages={
          1710-8
        }
}
Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune blistering diseases characterized by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. The role of classical cadherins as immunological targets of pemphigus autoantibodies is unknown. In this study, we tested the reactivity of sera from patients with PF, Fogo Selvagem (FS), and PV by immunoprecipitation coupled with immunoblotting (IP-IB) and ELISA techniques using a baculovirus-expressed ectodomain of E-cadherin… CONTINUE READING
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