E-cadherin gene mutations in human gastric carcinoma cell lines.

@article{Oda1994EcadherinGM,
  title={E-cadherin gene mutations in human gastric carcinoma cell lines.},
  author={Tatsuya Oda and Yae Kanai and Tetsunari Oyama and Kenta Yoshiura and Yutaka Shimoyama and Walter Birchmeier and Takashi Sugimura and Setsuo Hirohashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 5},
  pages={1858-62}
}
Reduced expression of E-cadherin has been regarded as one of the main molecular events involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion and metastasis. However, even with a sufficient amount of E-cadherin, cell-cell adhesion is sometimes lost in "diffusely invasive" human carcinomas. Ten human cancer cell lines, showing growth characterized morphologically by loose cell-cell adhesion, were analyzed for possible structural abnormalities of their expressed E… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

Similar Papers

Loading similar papers…