E-cadherin gene mutations in human gastric carcinoma cell lines.

  title={E-cadherin gene mutations in human gastric carcinoma cell lines.},
  author={Tatsuya Oda and Yae Kanai and Tetsunari Oyama and Kenta Yoshiura and Yutaka Shimoyama and Walter Birchmeier and Takashi Sugimura and Setsuo Hirohashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 5},
Reduced expression of E-cadherin has been regarded as one of the main molecular events involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion and metastasis. However, even with a sufficient amount of E-cadherin, cell-cell adhesion is sometimes lost in "diffusely invasive" human carcinomas. Ten human cancer cell lines, showing growth characterized morphologically by loose cell-cell adhesion, were analyzed for possible structural abnormalities of their expressed E… CONTINUE READING


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