E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line.

@article{Boyer1992EcadherinED,
  title={E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line.},
  author={Brigitte Boyer and Sylvie Dufour and Jean Paul Thiery},
  journal={Experimental cell research},
  year={1992},
  volume={201 2},
  pages={
          347-57
        }
}
Cell dissociation and acquisition of cell motility are major events in morphogenesis, wound repair, and cancer invasion and metastasis. We have used the NBT-II bladder carcinoma cell line as a model system to study the mechanisms of these events. Upon exposure to acidic fibroblast growth factor (aFGF), NBT-II cells undergo morphological changes that resemble those described in epithelial-mesenchymal transitions, i.e., dissociation of some or all polygonal epithelial cells and their… CONTINUE READING
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