E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells

@article{Santis2009EcadherinDC,
  title={E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells},
  author={Giuseppina De Santis and Silvia Miotti and Mimma Mazzi and Silvana Canevari and Antonella Tomassetti},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1206-1217}
}
E-cadherin (cadh), a member of a family of integral membrane glycoproteins that represent the major component of adherens junctions (AJs), mediates cell–cell adhesion through the calcium-dependent homophilic interaction of its extracellular domain. Metastatic human carcinomas frequently lose E-cadh expression, whereas epithelial ovarian cancer (EOCs… CONTINUE READING