E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.

@article{Owens2000EcadherinAT,
  title={E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.},
  author={Dewi W Owens and Valerie G Brunton and Eric Kenneth Parkinson and Magaret C Frame},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={269 2},
  pages={369-76}
}
The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro. 

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