E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

@article{Gosavi2010EcadherinAP,
  title={E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly},
  author={Prajakta Gosavi and Samrat T. Kundu and Nileema Khapare and Lalit Sehgal and Mansi S. Karkhanis and Sorab N. Dalal},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={1439-1454}
}
A decrease in the levels of the desmosomal plaque protein, plakophilin3 (PKP3), leads to a decrease in desmosome size and cell-cell adhesion. To test the hypothesis that PKP3 is required for desmosome formation, the recruitment of desmosomal components to the cell surface was studied in the PKP3 knockdown clones. The PKP3 knockdown clones showed decreased cell border staining for multiple desmosomal proteins, when compared to vector controls, and did not form desmosomes in a calcium switch… CONTINUE READING