E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer.

  title={E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer.},
  author={Jacqueline Miranda de Lima and Lessileia Gomes de Souza and Ismael D C G da Silva and Nora Manoukian Forones},
  journal={The International journal of biological markers},
  volume={24 2},
PURPOSE E-cadherin (CDH1) and metalloproteinase (MMP) polymorphisms could play a crucial role in cancer invasion. Our aim was to investigate the influence of the -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 polymorphisms on the frequency and progression of colorectal cancer (CRC). EXPERIMENTAL DESIGN A total of 130 patients with CRC and 130 noncancer controls were studied. The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 genotypes were analyzed by polymerase chain reaction… CONTINUE READING


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