E-cadherin and beta-catenin are down-regulated in prostatic bone metastases.

  title={E-cadherin and beta-catenin are down-regulated in prostatic bone metastases.},
  author={A A Gordon Bryden and Judith A Hoyland and Anthony John Freemont and Noel W. Clarke and D Schembri Wismayer and Nicholas J. R. George},
  journal={BJU international},
  volume={89 4},
OBJECTIVE To determine the E-cadherin and beta-catenin expression phenotype in untreated primary prostate cancer and corresponding bone metastases. MATERIALS AND METHODS Paired bone metastasis and primary prostate specimens were obtained from 14 men with untreated metastatic prostate carcinoma. The tumours were histologically graded by an independent pathologist. Expression of mRNA for E-cadherin and beta-catenin was detected within the tumour cells using in-situ hybridization with a 35S… CONTINUE READING

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