E-cadherin: Its dysregulation in carcinogenesis and clinical implications.

  title={E-cadherin: Its dysregulation in carcinogenesis and clinical implications.},
  author={Sonia How Ming Wong and Chee-Mun Fang and Lay Hong Chuah and Chee Onn Leong and Siew Ching Ngai},
  journal={Critical reviews in oncology/hematology},
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E… CONTINUE READING
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