E-cadherin, N-cadherin, and calretinin in pleural effusions: the good, the bad, the worthless.

@article{Simsir1999EcadherinNA,
  title={E-cadherin, N-cadherin, and calretinin in pleural effusions: the good, the bad, the worthless.},
  author={Aylin Simsir and Patricia A. Fetsch and Dipti Mehta and Maureen F. Zakowski and Andrea Abati},
  journal={Diagnostic cytopathology},
  year={1999},
  volume={20 3},
  pages={125-30}
}
The distinction between reactive mesothelial cells (RMC), malignant mesothelioma (MM), and metastatic adenocarcinoma (ACA) in pleural effusions may be impossible based on morphology alone. E-cadherin, N-cadherin, and calretinin are newly described immunocytochemical markers which can potentially be utilized for facilitating this distinction. E-cadherin and N-cadherin are calcium-dependent intercellular adhesion molecules expressed in epithelial cells and mesenchymal/mesothelial cells… CONTINUE READING

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