E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.

@article{Tamura2000ECadherinGP,
  title={E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.},
  author={Gen Tamura and Jie‐yun Yin and Suna Wang and Albert Steven Fleisher and Tong Tong Zou and Joshua Matt Abraham and Dehe Kong and Kara N. Smolinski and Keith T Wilson and Stephen P. James and Steven G. Silverberg and Satoshi S Nishizuka and Masanori Terashima and Teiichi Motoyama and Stephen J. Meltzer},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 7},
  pages={
          569-73
        }
}
BACKGROUND E (epithelial)-cadherin, the cell adhesion molecule also considered a potential invasion/metastasis suppressor, is mutationally inactivated in nearly half of all undifferentiated-scattered (diffuse-type) gastric carcinomas. In addition, silencing of E-cadherin by CpG methylation within its promoter region has been reported in several gastric carcinoma cell lines. We investigated the methylation status of the E-cadherin promoter region in 53 primary human gastric carcinomas. METHODS… CONTINUE READING

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