E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat

@article{Kendall2010E6801A5,
  title={E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat},
  author={Ian Kendall and Helge A. Slotten and Xavier Codony and Javier Burgueño and Petrus J. Pauwels and Jos{\'e} Miguel Vela and Kevin C.F. Fone},
  journal={Psychopharmacology},
  year={2010},
  volume={213},
  pages={413-430}
}
Rationale and objectivesIn rats, 5-hydroxytryptamine6 (5-HT6) receptor antagonists improve learning and memory, but the effects of agonists are poorly defined. This study investigated the effects of 5-HT6 receptor agonists and antagonists on a rodent model of recognition memory.MethodsSelective 5-HT6 receptor agonists and antagonists were administered either alone, after a scopolamine-induced impairment, or combined with sub-effective doses of the acetylcholinesterase inhibitor, donepezil, or… 
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