E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats.

@article{Ray2000E64dPB,
  title={E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats.},
  author={Swapan K Ray and D C Matzelle and Gloria Gant Wilford and Edward Leo Hogan and Naren Lal Banik},
  journal={Brain research},
  year={2000},
  volume={867 1-2},
  pages={80-9}
}
Calpain, a Ca(2+)-dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in SCI, we treated injured rats with E-64-d, a cell permeable and selective inhibitor of calpain. SCI was induced on T12 by the weight-drop (40 g-cm force) method. Within 15 min, E-64-d (1 mg/kg) in 1.5% DMSO was administered i.v. to the SCI rats… CONTINUE READING

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