E 2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain : Transactivation is mediated by the conserved amino-terminal domain ( transcriptional regulation / DNA-protein interaction )

@inproceedings{McBrideE2P,
  title={E 2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain : Transactivation is mediated by the conserved amino-terminal domain ( transcriptional regulation / DNA-protein interaction )},
  author={Alison A. McBride and J C Byrne and Peter M Howley}
}
The E2 open reading frame (ORF) of bovine papillomavirus type 1 (BPV-1) encodes positiveand negativeacting factors that regulate viral gene expression. The fulllength ORF encodes a transactivator, and two transcriptional repressors are expressed from the 3' half of the ORF. Previous analysis has shown that a conserved C-terminal region of 101 amino acids, which is shared by E2 transactivator and repressor proteins, contains the specific DNA binding activity. Further analysis of the E2… CONTINUE READING