Dystrophinopathy-associated dysfunction of Krebs cycle metabolism

@article{Lindsay2019DystrophinopathyassociatedDO,
  title={Dystrophinopathy-associated dysfunction of Krebs cycle metabolism},
  author={Angus Lindsay and Christopher M Chamberlain and Bruce A. Witthuhn and Dawn A. Lowe and James M. Ervasti},
  journal={Human Molecular Genetics},
  year={2019},
  volume={28},
  pages={942–951}
}
  • Angus Lindsay, Christopher M Chamberlain, +2 authors James M. Ervasti
  • Published in Human molecular genetics 2019
  • Biology, Medicine
  • Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of dystrophin protein. Studies suggest that metabolic alterations are important to disease pathogenesis. Because muscle accounts for ~40% of body mass, we hypothesized that dystrophy-mediated metabolic changes would be measurable in biofluids and that a metabolomic analysis of urine would provide insight into the metabolic status of dystrophic muscle. Using the mdx mouse model, we performed a large-scale metabolomic… CONTINUE READING

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