Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.

@article{Acharyya2005DystrophinGC,
  title={Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.},
  author={Swarnali Acharyya and Matthew E R Butchbach and Zarife Sahenk and Huating Wang and Motoyasu Saji and Micheal Carathers and Matthew D. Ringel and Richard John Edward. Skipworth and Kenneth C. H. Fearon and Michael Anthony Hollingsworth and Peter Jr. Muscarella and Arthur H. M. Burghes and Jill A Rafael-Fortney and Denis C. Guttridge},
  journal={Cancer cell},
  year={2005},
  volume={8 5},
  pages={
          421-32
        }
}
Cachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined. We report that tumor-induced alterations in the muscular dystrophy-associated dystrophin glycoprotein complex (DGC) represent a key early event in cachexia. Muscles from tumor-bearing mice exhibited membrane abnormalities accompanied by reduced levels of dystrophin and increased glycosylation on DGC proteins. Wasting was accentuated in tumor… CONTINUE READING
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