Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.

@article{Klymiuk2013DystrophindeficientPP,
  title={Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.},
  author={Nikolai Klymiuk and Andreas Blutke and Alexander Graf and Sabine Krause and Katinka Burkhardt and Annegret Wuensch and Stefan Krebs and Barbara Kessler and Valeri Zakhartchenko and Mayuko Kurome and Elisabeth Kemter and Hiroshi Nagashima and Benedikt Schoser and Nadja Herbach and Helmut Blum and Ruediger Wanke and Annemieke Aartsma-Rus and Christian Thirion and Hanns Lochm{\"u}ller and Maggie C. Walter and Eckhard Wolf},
  journal={Human molecular genetics},
  year={2013},
  volume={22 21},
  pages={4368-82}
}
Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin (DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death. To establish a tailored large animal model of DMD, we deleted DMD exon 52 in male pig cells by gene targeting and generated offspring by nuclear transfer. DMD pigs exhibit absence of dystrophin in skeletal muscles, increased serum creatine kinase levels, progressive dystrophic changes of skeletal… CONTINUE READING
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