Dystrophin-deficient cardiomyopathy in mouse: Expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

@article{Spurney2008DystrophindeficientCI,
  title={Dystrophin-deficient cardiomyopathy in mouse: Expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart},
  author={Christopher F Spurney and Susan Knoblach and Emidio E. Pistilli and Kanneboyina Nagaraju and Eric P. Hoffman},
  journal={Neuromuscular Disorders},
  year={2008},
  volume={18},
  pages={371-381}
}
Duchenne muscular dystrophy (DMD; dystrophin-deficiency) causes dilated cardiomyopathy in the second decade of life in affected males. We studied the dystrophin-deficient mouse heart (mdx) using high-frequency echocardiography, histomorphometry, and gene expression profiling. Heart dysfunction was prominent at 9-10months of age and showed significantly increased LV internal diameter (end systole) and decreased posterior wall thickness. This cardiomyopathy was associated with a 30% decrease in… CONTINUE READING

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