Dystrophin constitutes 5% of membrane cytoskeleton in skeletal muscle.

@article{Ohlendieck1991DystrophinC5,
  title={Dystrophin constitutes 5% of membrane cytoskeleton in skeletal muscle.},
  author={Kay Ohlendieck and Kevin P Campbell},
  journal={FEBS letters},
  year={1991},
  volume={283 2},
  pages={230-4}
}
Dystrophin, which is absent in skeletal muscle of Duchenne muscular dystrophy patients, has not been considered to play a major structural role in the cell membrane of skeletal muscle because of its low abundance (approximately 0.002% of total muscle protein). Here, we have determined the relative abundance of dystrophin in a membrane cytoskeleton preparation and found that dystrophin constitutes approximately 5% of the total membrane cytoskeleton fraction of skeletal muscle sarcolemma. In… CONTINUE READING