Dystrophin and utrophin bind actin through distinct modes of contact.

@article{Rybakova2006DystrophinAU,
  title={Dystrophin and utrophin bind actin through distinct modes of contact.},
  author={Inna N. Rybakova and Jill L. Humston and Kevin J. Sonnemann and James M. Ervasti},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 15},
  pages={9996-10001}
}
This study was designed to define the molecular epitopes of dystrophin-actin interaction and to directly compare the actin binding properties of dystrophin and utrophin. According to our data, dystrophin and utrophin both bound alongside actin filaments with submicromolar affinities. However, the molecular epitopes involved in actin binding differed between the two proteins. In utrophin, the amino-terminal domain and an adjacent string of the first 10 spectrin-like repeats more fully… CONTINUE READING

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