Dystrophic phenotype induced in vitro by antibody blockade of muscle alpha-dystroglycan-laminin interaction.

@article{Brown1999DystrophicPI,
  title={Dystrophic phenotype induced in vitro by antibody blockade of muscle alpha-dystroglycan-laminin interaction.},
  author={Susan Carol Brown and Ariberto Fassati and L Popplewell and Anton M. Page and M. David Henry and Kevin P Campbell and George Dickson},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 2)},
  pages={209-16}
}
alpha-dystroglycan is a glycoprotein expressed on the surface of skeletal muscle fibres and other cell types. In muscle, alpha-dystroglycan provides a link between the myofibre cytoskeleton through its indirect binding to dystrophin, and the basal lamina through its binding to laminin-2, a protein of the extracellular matrix. The disruption of this linkage between the myofibre cytoskeleton and the extracellular matrix is a common feature of Duchenne and other muscular dystrophies, though the… CONTINUE READING
33 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…