Dystrophic neurites of senile plaques in Alzheimer’s disease are deficient in cytochrome c oxidase

@article{PrezGracia2008DystrophicNO,
  title={Dystrophic neurites of senile plaques in Alzheimer’s disease are deficient in cytochrome c oxidase},
  author={Esther P{\'e}rez-Gracia and Benjam{\'i}n Torrej{\'o}n-Escribano and Isidro Ferrer},
  journal={Acta Neuropathologica},
  year={2008},
  volume={116},
  pages={261-268}
}
Double-labeling immunofluorescence and confocal microscopy have been used to learn about the local relationship between amyloid, mitochondria, and cytochrome c oxidase (COX) in dystrophic neurites of senile plaques in the frontal cortex in Alzheimer's disease (AD). Dystrophic neurites surrounding amyloid plaques are filled with mitochondrial porin-immunoreactive structures. In contrast with tangle-bearing and non-tangle-bearing neurons, which express mitochondrial porin and COX subunit 4, porin… CONTINUE READING