Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway

  title={Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway},
  author={Cathy Sirour and Magdalena Hidalgo and Val{\'e}rie Bello and Nicolas P Buisson and Thierry Darrib{\`e}re and Nicole Moreau},
  booktitle={Molecular biology of the cell},
Dystroglycan (Dg) is a transmembrane protein involved both in the assembly and maintenance of basement membrane structures essential for tissue morphogenesis, and the transmission of signals across the plasma membrane. We used a morpholino knockdown approach to investigate the function of Dg during Xenopus laevis skin morphogenesis. The loss of Dg disrupts epidermal differentiation by affecting the intercalation of multiciliated cells, deposition of laminin, and organization of fibronectin in… CONTINUE READING
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