Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice.

@article{Williamson1997DystroglycanIE,
  title={Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice.},
  author={Richard A Williamson and M. David Henry and Karla J. Daniels and Ron F. Hrstka and Jane Constance Lee and Yoshihide Sunada and O Ibraghimov-Beskrovnaya and Kevin P Campbell},
  journal={Human molecular genetics},
  year={1997},
  volume={6 6},
  pages={831-41}
}
Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC), a protein assembly that plays a critical role in a variety of muscular dystrophies. In order to better understand the function of dystroglycan in development and disease, we have generated a null allele of dystroglycan (Dag1neo2) in mice. Heterozygous Dag1neo2 mice are viable and fertile. In contrast, homozygous Dag1neo2 embryos exhibit gross developmental abnormalities beginning around 6.5 days of gestation… CONTINUE READING
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