Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte.

@article{Poulton2006DystroglycanDL,
  title={Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte.},
  author={John S. Poulton and Wu-Min Deng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 34},
  pages={
          12775-80
        }
}
Anterior-posterior axis formation in the Drosophila oocyte requires activation of the EGF receptor (EGFR) pathway in the posterior follicle cells (PFC), where it also redirects them from the default anterior to the posterior cell fate. The relationship between EGFR activity in the PFC and oocyte polarity is unclear, because no EGFR-induced changes in the PFC have been observed that subsequently affect oocyte polarity. Here, we show that an extracellular matrix receptor, Dystroglycan, is down… CONTINUE READING
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