Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts.

  title={Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts.},
  author={Sheldon E. Litwin and Dongfang Zhang and John H. B. Bridge},
  journal={Circulation research},
  volume={87 11},
The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) transients during field stimulation in left ventricular (LV) myocytes from control and infarcted hearts (3 weeks). Compared with controls, Ca(2+) transients in myocytes adjacent to the… CONTINUE READING


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