Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver.

@article{Zhang2013DysregulationsOU,
  title={Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver.},
  author={Lifang Zhang and Xiaoman Chu and Hong Wang and Hao Xie and Cen Guo and Lijuan Cao and Xueyan Zhou and Guangji Wang and Haiping Hao},
  journal={European journal of pharmacology},
  year={2013},
  volume={721 1-3},
  pages={
          277-85
        }
}
Both high fat diet (HFD) and valproic acid (VPA) interfere with mitochondrial β-oxidation of fatty acids, which subsequently triggers microvesicular fatty liver and hepatic dysfunction. UDP-glucuronosyltransferases, the major phase II drug metabolism enzymes, play a pivotal role in detoxifying various exogenous and endogenous compounds. This study aimed to investigate the dysregulation patterns of major UDP-glucuronosyltransferases (UGTs) induced by VPA and/or HFD. Biochemical and… CONTINUE READING
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