Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

@inproceedings{Begg2015DysregulationOT,
  title={Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae},
  author={Stephanie L Begg and Bart A Eijkelkamp and Zhenyao Luo and Rafael M Cou{\~n}ago and Jacqueline R. Morey and Megan Maher and Cheryl-Lynn Y Ong and Alastair G. McEwan and Bostjan Kobe and Megan L. O'Mara and James C. Paton and Christopher A McDevitt},
  booktitle={Nature communications},
  year={2015}
}
Cadmium is a transition metal ion that is highly toxic in biological systems. Although relatively rare in the Earth's crust, anthropogenic release of cadmium since industrialization has increased biogeochemical cycling and the abundance of the ion in the biosphere. Despite this, the molecular basis of its toxicity remains unclear. Here we combine metal-accumulation assays, high-resolution structural data and biochemical analyses to show that cadmium toxicity, in Streptococcus pneumoniae, occurs… CONTINUE READING
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