Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ.

Abstract

Testicular germ cell tumours (TGCT) of young adults arise from the intratubular precursor, carcinoma in situ (CIS). CIS cells are thought to be developmentally arrested and transformed fetal germ cells that survive through childhood and gain invasive capacity after puberty. Given that germ cell neoplasms arise frequently in undervirilized and dysgenetic… (More)
DOI: 10.1002/path.4154

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