Dysregulation of the Wnt/beta-catenin signaling pathway in canine cutaneous melanotic tumor.

@article{Han2010DysregulationOT,
  title={Dysregulation of the Wnt/beta-catenin signaling pathway in canine cutaneous melanotic tumor.},
  author={J I Han and Dae-Yong Kim and K-J Na},
  journal={Veterinary pathology},
  year={2010},
  volume={47 2},
  pages={285-91}
}
The Wnt/beta-catenin signal transduction pathway is important in many developmental processes and during tumorigenesis. beta-Catenin acts as a signal transducer. To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 18 formalin-fixed paraffin-embedded canine cutaneous melanotic tumor tissues were examined. For cloning and sequencing of the full-length canine ctnnb1 gene encoding beta-catenin, conserved sequences of the human and… CONTINUE READING