Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System.

@article{Spath2017DysregulationOT,
  title={Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System.},
  author={Sabine Spath and Juliana Komuczki and Mario Hermann and Pawel Pelczar and Florian Mair and Bettina Schreiner and Burkhard Becher},
  journal={Immunity},
  year={2017},
  volume={46 2},
  pages={245-260}
}
Chronic inflammatory diseases are influenced by dysregulation of cytokines. Among them, granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic function of T cells in preclinical models of autoimmunity. To study the impact of dysregulated GM-CSF expression in vivo, we generated a transgenic mouse line allowing the induction of GM-CSF expression in mature, peripheral helper T (Th) cells. Antigen-independent GM-CSF release led to the invasion of inflammatory… CONTINUE READING