Dysregulation of thalamic sensory ‘transmission’ in schizophrenia: neurochemical vulnerability to hallucinations
@article{Behrendt2006DysregulationOT, title={Dysregulation of thalamic sensory ‘transmission’ in schizophrenia: neurochemical vulnerability to hallucinations}, author={R. Behrendt}, journal={Journal of Psychopharmacology}, year={2006}, volume={20}, pages={356 - 372} }
Cholinergic arousal mechanisms predispose thalamic and cortical neurons to fire action potentials at gamma rhythms, which have a tendency to resonate in thalamocortical networks, thereby forming coherent assemblies under constraints of sensory input to specific thalamic nuclei, on the one hand, and prefrontal and limbic attentional mechanisms, on the other. Perception may be based on sustained assemblies of coherent gamma oscillations in thalamocortical circuits. In schizophrenia, the impact of… CONTINUE READING
65 Citations
Visual hallucinations, thalamocortical physiology and Lewy body disease: A review
- Medicine
- Neuroscience & Biobehavioral Reviews
- 2019
- 7
Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia.
- Psychology, Medicine
- Medical hypotheses
- 2012
- 37
Dysfunctional thalamus-related networks in schizophrenia.
- Psychology, Medicine
- Schizophrenia bulletin
- 2011
- 90
- PDF
Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging.
- Psychology, Medicine
- Archives of general psychiatry
- 2012
- 46
- PDF
The Thalamic Reticular Nucleus in Schizophrenia and Bipolar Disorder: Role of Parvalbumin-Expressing Neuron Networks and Oxidative Stress
- Biology, Medicine
- Molecular Psychiatry
- 2017
- 58
- PDF
Thalamocortical connectivity during resting state in schizophrenia
- Psychology, Medicine
- European Archives of Psychiatry and Clinical Neuroscience
- 2013
- 92
Contribution of hippocampal region CA3 to consciousness and schizophrenic hallucinations
- Psychology, Medicine
- Neuroscience & Biobehavioral Reviews
- 2010
- 58
Hallucinatory experience as aberrant event memory formation: Implications for the pathophysiology of schizophrenia
- Medicine, Psychology
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 2016
- 10
Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia
- Psychology, Medicine
- Neuroscience Bulletin
- 2017
- 30
References
SHOWING 1-10 OF 194 REFERENCES
Hallucinations: Synchronisation of thalamocortical γ oscillations underconstrained by sensory input
- Medicine, Psychology
- Consciousness and Cognition
- 2003
- 77
Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
- Medicine
- Trends in Neurosciences
- 2001
- 145
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1992
- 450
- PDF
A systems model of altered consciousness: integrating natural and drug-induced psychoses
- Psychology, Medicine
- Brain Research Bulletin
- 2001
- 219
- PDF
Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems
- Chemistry, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1990
- 724
- PDF
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
- Biology, Medicine
- Nature
- 1996
- 472
Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia
- Psychology, Medicine
- Psychopharmacology
- 2003
- 328
Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex
- Psychology, Medicine
- Neuropsychopharmacology
- 2003
- 251
- PDF
Acetylcholine and Hallucinations - Disease-Related Compared to Drug-Induced Alterations in Human Consciousness
- Psychology, Medicine
- Brain and Cognition
- 1995
- 257
- PDF
Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia
- Psychology, Medicine
- Journal of neurochemistry
- 1999
- 237
- Highly Influential