Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Abstract

The phosphoinositide signaling system is a crucial regulator of neural development, cell survival, and plasticity. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negatively regulates phosphatidylinositol 3-kinase signaling and downstream targets. Nse-Cre Pten conditional knockout mice, in which Pten is ablated in granule cells of the dentate… (More)
DOI: 10.1073/pnas.1222803110

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@article{Takeuchi2013DysregulationOS, title={Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.}, author={Koichi Takeuchi and Michael J. Gertner and Jing Zhou and Luis F. Parada and Michael V. L. Bennett and R Suzanne Zukin}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2013}, volume={110 12}, pages={4738-43} }