Dysregulation of renal aquaporins and epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus.

@article{Nielsen2008DysregulationOR,
  title={Dysregulation of renal aquaporins and epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus.},
  author={J. Nielsen and T. Kwon and B. M. Christensen and J. Fr{\o}kiaer and S. Nielsen},
  journal={Seminars in nephrology},
  year={2008},
  volume={28 3},
  pages={
          227-44
        }
}
Lithium is used commonly to treat bipolar mood disorders. In addition to its primary therapeutic effects in the central nervous system lithium has a number of side effects in the kidney. The side effects include nephrogenic diabetes insipidus with polyuria, mild sodium wasting, and changes in acid/base balance. These functional changes are associated with marked structural changes in collecting duct cell composition and morphology, likely contributing to the functional changes. Over the past… Expand
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