Dysregulation of macrophage activation profiles by engineered nanoparticles.

  title={Dysregulation of macrophage activation profiles by engineered nanoparticles.},
  author={Vamsi Kodali and Matthew H Littke and Susan C. Tilton and Justin G. Teeguarden and Liang Shi and Charles W Frevert and Wei Wang and Joel G. Pounds and Brian D. Thrall},
  journal={ACS nano},
  volume={7 8},
Although the potential human health impacts from exposure to engineered nanoparticles (ENPs) are uncertain, past epidemiological studies have established correlations between exposure to ambient air pollution particulates and the incidence of pneumonia and lung infections. Using amorphous silica and superparamagnetic iron oxide (SPIO) as model high production volume ENPs, we examined how macrophage activation by bacterial lipopolysaccharide (LPS) or the lung pathogen Streptococcus pneumoniae is… CONTINUE READING
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