Dysregulation of dynorphins in Alzheimer disease.

  title={Dysregulation of dynorphins in Alzheimer disease.},
  author={Tatiana Yakovleva and Zoya Marinova and Alexander Kuzmin and Nabil G Seidah and Vahram Haroutunian and Lars Terenius and Georgy Bakalkin},
  journal={Neurobiology of aging},
  volume={28 11},
The opioid peptides dynorphins may be involved in pathogenesis of Alzheimer disease (AD) by inducing neurodegeneration or cognitive impairment. To test this hypothesis, the dynorphin system was analyzed in postmortem samples from AD and control subjects, and subjects with Parkinson or cerebro-vascular diseases for comparison. Dynorphin A, dynorphin B and related neuropeptide nociceptin were determined in the Brodmann area 7 by radioimmunoassay. The precursor protein prodynorphin, processing… CONTINUE READING
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