Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage.

@article{Wang2013DysregulationOC,
  title={Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage.},
  author={Xian-hui Wang and Fen Wang and Shou-jiang You and Yong-jun Cao and Li-dan Cao and Qiao Han and Chun-Feng Liu and Li-Fang Hu},
  journal={Cellular signalling},
  year={2013},
  volume={25 11},
  pages={2255-62}
}
Hydrogen sulfide (H2S), mainly produced by cystathionine γ-lyase (CSE) in vascular system, emerges as a novel gasotransmitter exerting anti-inflammatory and anti-atherosclerotic effects. Alterations of CSE/H2S pathway may thus be involved in atherosclerosis pathogenesis. However, the underlying mechanisms are poorly understood. The present study showed that… CONTINUE READING