Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease.

@article{Miller2010DysregulationOC,
  title={Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease.},
  author={Benjamin R. Miller and Adam G. Walker and Stephen J Fowler and Stephan von H{\"o}rsten and Olaf Riess and Michael L. Johnson and George V Rebec},
  journal={Neurobiology of disease},
  year={2010},
  volume={37 1},
  pages={106-13}
}
Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity of striatal neurons. We found that relative to wild-type controls, HD rats suffer from population-level deficits in striatal activity characterized by a loss of correlated firing and fewer episodes… CONTINUE READING
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