Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.

  title={Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.},
  author={Jing Shen and Gregory William Hruby and James M. McKiernan and Irina Gurvich and Michael Jeffrey Lipsky and Mitchell C. Benson and Regina M. Santella},
  journal={The Prostate},
  volume={72 13},
BACKGROUND It is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa). METHODS We examined the hypothesis that plasma miRNA levels can differentiate patients by aggressiveness in 82 PCa patients. Taqman based quantitative RT-PCR assays were performed to measure copy number of target miRNAs. RESULTS miR-20a was significantly overexpressed in plasma from patients with stage 3 tumors compared to stage 2 or below (P… CONTINUE READING
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