Dysregulation of catalase activity in newborn myocytes during hypoxia is mediated by c-Abl tyrosine kinase.

@article{Cabigas2015DysregulationOC,
  title={Dysregulation of catalase activity in newborn myocytes during hypoxia is mediated by c-Abl tyrosine kinase.},
  author={E. Bernadette Cabigas and Jie Liu and Archana Vidya Boopathy and Pao Lin Che and Brian H. Crawford and Gitangali Baroi and Srishti Bhutani and Ming Shen and Mary B. Wagner and Michael H. Davis},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2015},
  volume={20 1},
  pages={93-103}
}
In the adult heart, catalase (CAT) activity increases appropriately with increasing levels of hydrogen peroxide, conferring cardioprotection. This mechanism is absent in the newborn for unknown reasons. In the present study, we examined how the posttranslational modification of CAT contributes to its activation during hypoxia/ischemia and the role of c-Abl tyrosine kinase in this process. Hypoxia studies were carried out using primary cardiomyocytes from adult (>8 weeks) and newborn rats… CONTINUE READING
2 Extracted Citations
30 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…