Dysregulation of antiviral helicase pathways in systemic lupus erythematosus

Abstract

In the autoimmune disease systemic lupus erythematosus (SLE), our normal antiviral defenses are inappropriately activated, resulting in over-activity of the type I interferon (IFN) pathway. This increased activity of the type I IFN pathway is an important primary pathogenic factor in the disease. Emerging evidence has implicated the antiviral helicases in… (More)
DOI: 10.3389/fgene.2014.00418

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