Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients.

@article{Mayne1999DysregulationOA,
  title={Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients.},
  author={Michael Mayne and P Nicolas Shepel and Yi Jiang and Jonathan Geiger and Christopher Power},
  journal={Annals of neurology},
  year={1999},
  volume={45 5},
  pages={633-9}
}
Cytokines, including tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), have been implicated in the pathogenesis of multiple sclerosis (MS). The production and release of these cytokines are regulated in part by specific purinergic (adenosine) cell surface receptors. To determine the extent to which the adenosine A1 receptor influenced cytokine expression in peripheral blood mononuclear cells (PBMCs) from MS and control patients, we measured plasma adenosine and TNF alpha levels… CONTINUE READING

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