Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.

  title={Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.},
  author={B. Douglas White and Andy J. Chien and David W. Dawson},
  volume={142 2},
Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to mutations in Axin, adenomatous polyposis coli, and β-catenin that lead to constitutive hyperactivation of the pathway. However, Wnt/β-catenin signaling is also modulated through various other mechanisms in cancer, including cross talk with other altered signaling pathways. A more complex view of Wnt/β-catenin… CONTINUE READING
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