Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines

@inproceedings{UtoKonomi2012DysregulationOS,
  title={Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines},
  author={Ayako Uto-Konomi and Kosuke Miyauchi and Naoko Ozaki and Yasutaka Motomura and Yoshie Suzuki and Akihiko Yoshimura and Shinobu Suzuki and Daniel J. Cua and Masato Kubo},
  booktitle={PloS one},
  year={2012}
}
Homeostatic regulation of epidermal keratinocytes is controlled by the local cytokine milieu. However, a role for suppressor of cytokine signaling (SOCS), a negative feedback regulator of cytokine networks, in skin homeostasis remains unclear. Keratinocyte specific deletion of Socs3 (Socs3 cKO) caused severe skin inflammation with hyper-production of IgE, epidermal hyperplasia, and S100A8/9 expression, although Socs1 deletion caused no inflammation. The inflamed skin showed constitutive STAT3… CONTINUE READING