Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

@inproceedings{Damodaran2017DysregulationOS,
  title={Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes},
  author={Shivashankar Damodaran and Nathan A. Damaschke and Joseph C. Gawdzik and Bing Yang and Cedric Shi and Glenn O. Allen and Wei Huang and John M Denu and David Frasier Jarrard},
  booktitle={BMC Cancer},
  year={2017}
}
Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and opposed by the deacetylase Sirtuin2 (SIRT2). As these enzymes represent an important target for cancer therapy, we sought to determine whether the underlying genes are altered during prostate cancer (PCa) progression… CONTINUE READING
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