Dysregulation of Met receptor tyrosine kinase activity in invasive tumors.

@article{DanilkovitchMiagkova2002DysregulationOM,
  title={Dysregulation of Met receptor tyrosine kinase activity in invasive tumors.},
  author={Alla Danilkovitch-Miagkova and Berton Zbar},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 7},
  pages={863-7}
}
The MET protooncogene was discovered because of the ability of oncogenic Met to mediate chemically induced transformation of a human osteogenic sarcoma cell line (1). The normal product of this gene, Met, is an unusual receptor tyrosine kinase that can be distinguished from most other such proteins on the basis of its biosynthesis and its structural features. This transmembrane protein is synthesized as a single-chain precursor, which undergoes intracellular proteolytic cleavage at a basic… CONTINUE READING