Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice.

@article{Qin2011DysregulationOK,
  title={Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice.},
  author={Song Qin and Menglu Liu and Wenze Niu and Chun-Li Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 52},
  pages={21117-21}
}
Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differentiation. Unexpectedly, enhanced expression of KLF4 reduces self-renewal of cultured NSCs and inhibits proliferation of subventricular neural precursors in transgenic mice. Mice… CONTINUE READING

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