Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.

@article{Marcondes2008DysregulationOI,
  title={Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.},
  author={A. Mario Q. Marcondes and Andrew J Mhyre and Derek L. Stirewalt and Soo-Hyun Kim and Charles A Dinarello and H Joachim Deeg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 8},
  pages={2865-70}
}
TNFalpha levels are elevated in the marrows of patients with myelodysplastic syndrome (MDS) and are associated with high rates of apoptosis, which contributes to hematopoietic failure. We observed that exposure of human marrow stroma cell lines HS5 and HS27a to TNFalpha increases levels of IL-32 mRNA. IL-32, in turn, induces TNFalpha. Marrow stroma from patients with MDS expressed 14- to 17-fold higher levels of IL-32 mRNA than healthy controls. In contrast, cells from patients with chronic… CONTINUE READING

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