Dysregulation of HSG triggers vascular proliferative disorders

@article{Chen2004DysregulationOH,
  title={Dysregulation of HSG triggers vascular proliferative disorders},
  author={Kuang-Hueih Chen and Xiaomei Guo and Dalong Ma and Yanhong Guo and Qian Li and Dongmei Yang and Pengfei Li and Xiaoyan J Qiu and Shaojun Wen and Rui-ping Xiao and Jian Wu Tang},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={872-883}
}
Vascular proliferative disorders, such as atherosclerosis and restenosis, are the most common causes of severe cardiovascular diseases, but a common molecular mechanism remains elusive. Here, we identify and characterize a novel hyperplasia suppressor gene, named HSG (later re-named rat mitofusin-2). HSG expression was markedly reduced in hyper-proliferative vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rat arteries, balloon-injured Wistar Kyoto rat arteries, or ApoE… CONTINUE READING
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